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What are acylated alpha glucans and why does acylation matter?

by Production Team on Mar 16, 2026
What are acylated alpha glucans and why does acylation matter?

So what is so important about acylated alpha-glucans anyway?


If you can’t remember your chemistry classes from school, acyl groups are a carbon atom double bonded to an oxygen and single bonded to a carbon chain or hydrogen. 


Acylated alpha-glucans are low molecular weight and highly soluble.  This increases their bioavailability, or the ability for your body to quickly incorporate them to strengthen the natural immune system defences of your body, helping to spur Natural Killer (NK) cells and Macrophages to be ready to fight pathogens such as bacteria and viruses.  


Additionally, these compounds can help to enhance cytokine signaling and T-Cell responses, are ways your body “remembers” and responds to infections as well as reduce inflammation. 

 

https://pubmed.ncbi.nlm.nih.gov/9635925/ 


How do we know what is acylated?


Acylation is actually not the easiest thing to prove in a laboratory.  It requires specialized equipment called HPLC (High Performance Liquid Chromatography).  This is a sensitive process where compounds are separated using high pressure in a liquid column using a special solvent.  


Nature Helix performs these tests to assure the presence of several different types of acyl groups that help the alpha glucans in our Active Hexose Correlated Compound be more bioavailable.


Why don’t all companies do this?


Not many companies choose to go through the extra expense to assure they have the highest quality Active Hexose Correlated Compound.  Cheap knockoff brands that use fruiting bodies aren’t even following the correct patent for Active Hexose Correlated Compound, and they justify  use of  that term loosely.  


Verify that your Active Hexose Correlated Compound uses acylated Alpha Glucans by checking the label. 

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