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What are acylated alpha glucans and why does acylation matter?

by Production Team on Mar 16, 2026
What are acylated alpha glucans and why does acylation matter?

So what is so important about acylated alpha-glucans anyway?


If you can’t remember your chemistry classes from school, acyl groups are a carbon atom double bonded to an oxygen and single bonded to a carbon chain or hydrogen. When acyl groups attach to a glucan, the glucan is described as “acylated.”


Acylation is a structural feature that distinguishes the alpha-glucans in Active Hexose Correlated Compound. Research has explored how these compounds may support your body’s natural immune defenses, including the activity of natural killer (NK) cells and macrophages, which help fight pathogens such as bacteria and viruses.


Studies have also looked at their effects on cytokine signaling and T-cell responses, which are part of how your body “remembers” and responds to infections.

 

 

https://pubmed.ncbi.nlm.nih.gov/9635925/ 


How do we know what is acylated?


Acylation is actually not the easiest thing to confirm in a laboratory.  It requires specialized equipment, such as mass spectrometry, to detect acyl groups attached to glucose units.

 

Nature Helix has had Actexa tested by an independent laboratory using flow-injection mass spectrometry, and the results indicated the presence of acylated glucose units.


Why don’t all companies do this?


Not many companies choose to go through the extra expense to assure they have the highest quality Active Hexose Correlated Compound.  Cheap knockoff brands that use fruiting bodies aren’t following the mycelia-based process that Active Hexose Correlated Compound is known for, and they use the term loosely.


Verify that your Active Hexose Correlated Compound uses acylated Alpha Glucans by checking the label. 

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